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Re: SSRI's and Osteoporosis » Karen's World

Posted by seldomseen on September 14, 2008, at 9:57:57

In reply to Re: SSRI's and Osteoporosis, posted by Karen's World on September 13, 2008, at 23:25:15

I wouldn't be too quick to jump off the SSRI bandwagon, especially if they are working for you. Each of the studies you quoted (especially in the one in archives of internal medicine) has significant flaws.

Press releases regarding the studies tend to overgeneralize results.

There is something called *confounding by indication* which complicates each of the studies. In its simplest form, this confounder makes it impossible to determine whether the underlying illness or the drug taken for it causes the condition.

In my opinion, ideally, the studies would form a cohort of depressed people who aren't being treated and those depressed subjects that are and look at the outcome of osteoporosis.

This study design has some significant ethical problems as you may imagine.

 

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