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Re: Melancholic depression - what med is the best choi

Posted by Racer on September 10, 2008, at 10:27:17

In reply to Melancholic depression - what med is the best choi, posted by hansi555 on September 8, 2008, at 13:49:40

Hm... You don't say why you want to change, so I'm not sure how helpful this might be...

First, flip as it sounds, "the best med is the one that works for you," since we mostly react differently to meds. I also have classic melancholic features, and have found Wellbutrin a good choice, though it's never brought me to anything that could be called remission.

A TCA might be a good choice, depending on how well you tolerate it. The biggest appeal to the newer drugs is that they have fewer side effects than the TCAs and MAOIs. They're often more reliable than the newer drugs, though, so that's a good direction to look in.

What about Effexor, Cymbalta, or Pristiq? Those are very helpful for many people, and target multiple avenues for action.

Lithium is also a good choice for many, as is Lamictal. Lamictal has the benefit of fewer side effects, lithium is better known, since it's been used for a long time. It's a trade off -- which is a better choice to try first? Dunno -- they're both well worth discussing with your doctor.

I'm not sure what else to recommend, but thought I'd offer those thoughts. I hope they're helpful to you.

Good luck.


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