Posted by yxibow on August 3, 2008, at 1:44:44
In reply to Re: Also Pdoc Said Seroquel Being Aproved For Anxi, posted by linkadge on August 2, 2008, at 20:12:00
> >However, not everyone who takes Seroquel will >instantly gain large amounts of weight, and vice->versa for Zyprexa.
>
> True, but research is now suggesting that the drugs can induce metabolic changes in the absense of weight gain. Zyprexa, in particular, can screw with the pancreas in the absense of weight gain.
>
> Its not the side effects with warning signs that I am worried about, its about people getting diabeties without any warning signs.
>
> >A way of coming up with a plan to manage it >before it gets to a point is a good idea though. >Cutting down one's input calories is one sure >way of preventing it, but its rather hard I know >personally because its very easy to reach for >snacks.
>
> Serquel made me feel so ickey without any change in appetite. I don't think that diet and exercise are necessarily going to combat these issues as again, the drug may be directly affecting pancreatic function in the absense of weight gain.
>
> Thats not to say that diet and exercise aren't a good idea, theres just no proof that they do infact alter the neuroendocrine changes associted with these drugs.
>
> >As for its benefits for GAD, I would say its an >individual situation but it probably should be >something that should be used after other >methods have been tried.
>
> Yes, I agree. However it got an indication for GAD which may give the impression to doctors that the FDA concludes the risk/benifit ratio in GAD is favorable when it may not infact be. It may work for GAD, but theres so much more to consider.
>
> Also, to be honest, seroquel XR may be more dangerous than regular seroquel. The IR version's shorter half life may allow the body to have a necessary period of drug absence. If the drug is in the body constantly it may wreak more havok.
>
> For instance, in GAD with predominant insomnia (ie where it is essentially being used as a sleeping pill), the IR version is likely much safer and more effective, allowing an overal lower dosage and exposure timeframe.
>
> Linkadge
XR hasn't really been dispensed much from what I've heard because its considered a patent extender and not particularly novel in schizophrenia. Its been already known in psychiatric circles that even though it has a short half life of 6 hours, its the plasma life that is more important and for almost all patients once a day Seroquel has been the norm.
-- Jay
poster:yxibow
thread:843414
URL: http://www.dr-bob.org/babble/20080727/msgs/843850.html