Posted by jrbecker76 on July 26, 2008, at 23:51:36
In reply to Re: Like Trazodone for sleep but w/o heart problems » David_Hi, posted by Larry Hoover on July 26, 2008, at 21:52:00
> > So basically I'm looking for an anti-depressant with sedating properties like Trazodone but with no heart-related side-effects.
> >
> > Thanks
>
> The tricyclics doxepin, trimipramine, and amitriptyline are all used to promote sleep.
>
> Lar
>
>Nefazadone (Serzone) and Trazadone both metabolize into m-CPP, a serotonin agonist that causes a host of side effects, including chest pressure and heart palpitations. For most, the adverse events typically subside after initial titration and/or can be controlled by reducing your daily dosage. However, they can be a continual problem for some.
There is a new hypnotic class of 5-HT2 antagonists that will be on the market soon that will provide many of the benefits of nefazodone and trazadone, but with less of a side effect profile. Eplivanserin, which is a drug candidate from Sanofi-Aventis, should reach the market sometime next year. In the meantime, I would add to the other posters' recommendations by also throwing out there Rozerem (ramelteon). Some people find it does nothing, but many others report it gives them a great night's sleep with little residual effects in comparison to the GABA-A class of hypnotics (Ambien, Sonata, Lunesta). I take Rozerem in combination with a very low-dose of Nefazadone nightly.
JB
poster:jrbecker76
thread:842117
URL: http://www.dr-bob.org/babble/20080718/msgs/842236.html