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Re: EMSAM Success Story

Posted by SLS on July 19, 2008, at 13:33:11

In reply to Re: EMSAM Success Story » atmlady, posted by BrightEyed+Blueberry on July 19, 2008, at 11:25:18

I'm not 100% sure, but I believe that at 6mg/24hr, MAO-A is inhibited in the brain, even if not in the GI tract. The package insert says that Emsam inhibits both isoforms at antidepressant dosages. I think this is an important statement when trying to hypothesize what mechanism one is responding to.

"MAO exists as two isoenzymes, referred to as MAO-A and MAO-B. Selegiline has a greater affinity for MAO-B, compared to MAO-A. However, at antidepressant doses, selegiline inhibits both isoenzymes (see below)."

http://www.rxlist.com/cgi/generic/emsam_cp.htm


- Scott

 

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