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Re: MARPLAN anyone????

Posted by Tomatheus on July 17, 2008, at 23:15:40

In reply to MARPLAN anyone????, posted by maoi_wowee on July 17, 2008, at 19:54:02

maoi_wowee,

I took isocarboxazid (the generic version of Marplan) about two years ago for recurrent major depression, which has since progressed into schizoaffective disorder. Because I had a lot more success taking Nardil in enteric capsules than I did with the actual film-coated tablets, I tried taking isocarboxazid (another hydrazine-derivative MAOI) in the enteric capsules, as well.

My response to the isocarboxazid was similar to my response to the U.K. Goldshield-manufactured tranylcypromine: I had an excellent antidepressant response to the medication that lasted 3-4 days before losing most of the response. I tried increasing my dose to 20 mg/day and 30 mg/day, and each time I increased the dose, the same thing happened: 3-4 days of antidepressant relief, followed by practically nothing after that.

Compared with Nardil, which took several weeks to "kick in," I found isocarboxazid to be extremely fast-acting. The problem that I had with it, of course, is that the medication's wonderful start-up effect never lasted.

As far as I can tell, my response to isocarboxazid seems to be fairly atypical. Most patients do not respond to antidepressants for a few days only to lose their effects. But unfortunately, when I had recurrent major depression, I did.

Tomatheus


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poster:Tomatheus thread:840281
URL: http://www.dr-bob.org/babble/20080706/msgs/840359.html