Posted by Marty on July 1, 2008, at 15:31:06
In reply to Re: Hey Linkadge!, posted by linkadge on June 30, 2008, at 19:04:36
> While it is true that some studies have found >certain forms of brain atrophy associated with >long term, reccurent depression, there is >unfortunately very little proof that >antidepressants actually reduce this loss
>(Tianeptine aside).I'm surprised you say that "there is unfortunately very little proof that antidepressants actually reduce this loss
(Tianeptine aside)" ... Servier put most of their "marketting oriented research effort" on Tianeptine neurogenesis inducing properties and so it's true that this is an AD which has been documented extensively over this ability .. BUT .. is far from being the only AD which has been documented doing that .. most (all majors anyway) has been shown to induce neurogenesis (and other related "building" effects in the brain). Other class of meds also plays a role in reducing/reverting brain hippocampal atrophy... a short and -- VERY -- incomplete list just for the sake of example : tianeptine (affects structural plasticity in hippocampus and is an effective antidepressant); phenytoin (antiseizure and neuroprotective); fluoxetine (downregulates neurodegenerative enzyme and increases neuroprotective hippocampal S100 beta); lithium (neuroprotective and antiapoptotic); tricyclic antidepressants (increase hippocampal neurogenesis); antipsychotics (reduce hippocampal neuronal suppression) ...This list is from :
http://www.ncbi.nlm.nih.gov/pubmed/17098374?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum/\/\arty
poster:Marty
thread:836811
URL: http://www.dr-bob.org/babble/20080626/msgs/837511.html