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Re: Imipramine/Lexapro - have anything in common? brooke484

Posted by Marty on June 26, 2008, at 13:59:22

In reply to Imipramine/Lexapro - have anything in common?, posted by brooke484 on June 24, 2008, at 13:34:08

The only thing I see is that they are both very strong Serotonin Reuptake Inhibitor compared to much of the other AD of the SSRI and Tricyclic familly. In fact, Escitalopram (Lexapro) is the most selective (and so stronger) SSRI: escitalopram has the highest affinity for the human serotonin transporter (SERT) which is the thing AD needs to inhibite in order to reduce the reuptake of serotonine. Also Imipramine is said to have a strong SERT affinity.

Apart from that they have more differences than anything else. Escitalopram is the AD which 'plays' with the less stuff apart the SERT which make it the AD with (usually) less Side effects. While Imipramine 'plays' with about everything : norepinephrine, serotonin, dopamine, epinephrine, opiates, enkephalinase, histamine, muscarine, and acetylcholine. That makes it the LESS selective and Escitalopram the MOST selective.

I wonder how you would feel on a very small dose of Imipramine with a medium dose (or strong) of Escitalopram.... that could be very good for you I suspect.





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