Posted by SLS on June 17, 2008, at 15:18:41
In reply to Re: Paxil brand name superior to generic??? » SLS, posted by yxibow on June 17, 2008, at 14:38:50
> > > Next month i am going to try brand name paxil instead of this generic crap despite the cost.
> > >
> > > I know years ago when i switched from brand name to generic i felt worse.
> > >
> > > why on earth? i have no idea but my guess is that the generic is formulated differently.
> > >
> > > well i am sick of feeling like garbage.
> > >
> > > i was feeling better, less depressed, more social, etc etc.
> >
> > Yup. The generic paroxetine is demonstrably inferior to the name brand Paxil. My doctor has witnessed his patients relapse when they made the change from the name brand to the generic. I have heard of this phenomenon with paroxetine happening quite a few times.
> >
> > It would be interesting to know why this difference exists. However, it is not terribly important to know how. That this difference exists has been documented.
> >
> >
> > - Scott
>
>
>
> There is still the remore possibility of placebo effect. However, I'm not doubting these reports.
>
> If there is any difference, its probably because patients are not getting enough Paxil.
>
> It has a shorter half life than any of the SSRIs and must be taken daily as directed or withdrawals can occur within a dose or so.
>
> That's my guess -- which would mean upping the dose or paying a penalty copay (our great system in the states)
>
> -- jayYes. Increasing the dosage would make sense if the two preparations are not bioequivalent. Who knows how the differences in binders and excipients between the two preparations affect the delivery of the drug.
- Scott
poster:SLS
thread:834399
URL: http://www.dr-bob.org/babble/20080617/msgs/835099.html