Posted by SLS on June 1, 2008, at 5:28:04
In reply to Re: The best Tricyclic for anxiety...., posted by linkadge on May 31, 2008, at 19:45:23
> The TCA can be more tollerable than the SSRI's for some. Amitrpytaline is still considered a gold standard against which AD efficacy is measured.
>
> The TCA's also have a record of actually getting people *well*.At this point, it seems that Effexor is closest to the TCAs with respect to percentage of responders and quality of response.
Imipramine was considered to be the gold standard and was used as the standard comparator drug in clinical trials. However, amitriptyline is indeed somewhat better with regard to percentage of responders, and clomipramine better yet.
Regarding anxiety, some people experience an improvement with desipramine, especially once they begin to see the depression abate. Perhaps Linkadge knows of a receptor to which it binds other than NE alpha-1. Or perhaps there are NE pathways that are inhibitory upon the anxiogenic serotonergic tracts.
It is hard to say whether the anxiety is constantly in the background like GAD or a psychosocial consequence of being to asked to perform while in the depressed state.
- Scott
poster:SLS
thread:831465
URL: http://www.dr-bob.org/babble/20080528/msgs/832322.html