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Re: Medication Management: Episode 1

Posted by undopaminergic on May 16, 2008, at 3:02:49

In reply to Medication Management: Episode 1, posted by smart.drug on May 12, 2008, at 18:48:20

>
> I'm thinking of a combo of kava, valerian, tryptophan, and glutamine...
>

Last time I experimented with valerian, I had an attack of irritability and rage, the last of which is out of my usual characer. It may be a coincidence, but I'd be interested in knowing if others have noticed any such reactions to valerian.

> Would it do what I'm looking for? Would a medication like gabapentin be any better? Or how about a different strategy, with Rozerem?
>

Rozerem is a melatonin agonist - why not use the real thing instead? Melatonin can be useful for sleep, especially if you have a delayed sleep phase.

> Or should I try my luck with a sleep study, in the hopes of getting a narcolepsy diagnosis, and subsequently a prescription of Xyrem?
>

There are many cheaper and easier ways to get your hands on GHB (or GBL).

> See, if I take an anti-histamine, I drag my feet around and constantly nod off the next day.
>

Which anti-histamines have you tried? Probably due to it's antagonism of serotonin 5-HT2A-receptors, cyproheptadine (Periactin) is the best choice with regard to sleep quality, at least as judged on the basis of EEG. Mirtazapine (Remeron) and quetiapine (Seroquel) may be similarly effective in that they share the characteristics of 5-HT2A- and H1-antagonism, but especially mirtazapine's antagonism of alpha2-adrenergic receptors is likely to be detrimental to sleep.


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