Posted by SLS on March 30, 2008, at 18:12:44
In reply to to Scott about deplin and luvox, posted by bulldog2 on March 30, 2008, at 17:20:06
> > > Scott but does it only work with MAOI's Not luvox? Phillipa
> >
> > Dear Phillipa,
> >
> > I doubt anything will work for you in combination with Luvox.
> >
> > There are investigators who believe Deplin works for SSRI augmentation as well as antidepressants from other groups. The truth is, there is not enough clinical experience with Deplin to be able to infer its therapeutic value.
> >
> >
> > - Scott
>
> Any reason you believe Deplin would not work with Luvox?Nope.
I would love to see Deplin work as an effective augmenter to all standard antidepressants. However, so far, there haven't been enough success stories to be able to draw many inferences. The manufacturer of Deplin claims that it will increase the synthesis of NE, DA, and 5-HT by providing folate to participate in the enzymatic cycles. I think it accelerates the rate limiting steps by activating tyrosine hydroxylase and tryptophan hydroxylase. One could hypothesize that an MAOI would work additively to Deplin to increase the pool of available neurotransmitter for release.
For Phillipa, however, it doesn't seem that there is enough of an antidepressant response to Luvox to augment with Deplin. I guess I am just frustrated that she still be ill after all this time. If I were her, I would continue with Deplin for 2 - 3 months and swap out Luvox for Nardil should the former treatment prove inadequate.
- Scott
poster:SLS
thread:820107
URL: http://www.dr-bob.org/babble/20080330/msgs/820743.html