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Re: stimulant only - ADD/Depress./Anhedonia/'Norma

Posted by cumulative on March 13, 2008, at 23:16:09

In reply to stimulant only - ADD/Depress./Anhedonia/'Normalcy', posted by eric wagner on March 13, 2008, at 18:19:46

Unfortunately, the initial, bordering-on-hyperthymic mood lift from psychostimulants typically rapidly develops tolerance. This effect is related to dopaminergic activity in the nucleus accumbens, in response to which there is a rapid re-regulation. It's typically not something you can chase down, as adrenergic side effects rise. OTOH the therapeutic effects of improved concentration (perhaps a milder mood-lift as well) are separate and usually can last a very long time, or sensitize.


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