Posted by jms600 on February 23, 2008, at 10:27:51
In reply to Re: Lexapro for 2 weeks... now somethings gone wro, posted by Dopamine123 on February 21, 2008, at 17:20:24
> Anxiety from SSRI's is usually caused by increased activation of specific serotonin receptors. SSRI's increase serotonin in the synapse which activates multiple receptors.
>
> Agonist activation of the 5-HT1A receptor mediates the antidepressant/anti-anxiety effects of the SSRI's, while activation of 5-HT2A, 5-HT2C, 5-HT3 and several others, mediate the side effects (such as increased anxiety, insomnia).
>
> Seroquel blocks the 5-HT2A receptor and decreases serotonins effect there, which is good for anxiety/sleep. However It isn't an antagonist at other serotonin receptors.
>
> Risperidone is an antagonist at serotonin 5-HT2A receptors and 5-HT2C receptors.
>
> Remeron antagonizes the 5-HT2A, 5-HT2C, and 5-HT3 receptors.
>
> Ziprasidone is an antagonist at serotonin 5-HT2A, 5-HT2C receptors while being an agonist at 5-HT1A receptors.
>
> So you might want to try a different drug that gives you antagonistic action (decreasing serotonin effects) at 5-HT2A, 5-HT2C and 5-HT3 receptors while being agonist (increasing serotonins effect) at 5-HT1a receptors. That should give the best antidepressant/anti-anxiety effect.
>
> Hopes that's not too technical.
>
> My neuroscience/neurotechnology blog:
> http://brainstimulant.blogspot.com
From what you have written above, are you saying that Remeron would be the best AD for me to try?I have tried Remeron some time back, and I have to say it was the worst AD I have ever taken! It did nothing but exacerbate my anxiety. In fact, out of all the ADs I have tried Remeron has to be the worst!
poster:jms600
thread:812520
URL: http://www.dr-bob.org/babble/20080221/msgs/814242.html