Posted by Phoenix1 on January 16, 2008, at 22:17:49
In reply to Re: Thanks! » Phoenix1, posted by Jamal Spelling on January 16, 2008, at 13:41:49
> Does anyone have any thoughts on low dose flupentixol? It's a typical thioxanthene AP.
>
> Does anyone know the difference between sulpiride and amisulpride? They are both benzamide APs, apparently very similar. It seems many have used amisulpride, but what about sulpiride? Can it, too, be used to counteract anhedonia, possibly alongside and SSRI?Hi Jamal,
Take a look at this:
http://www.dr-bob.org/cgi-bin/pb/mget.pl?post=/babble/20041123/msgs/420491.html
And these:
http://www.ncbi.nlm.nih.gov/pubmed/15738862
http://www.biopsychiatry.com/amisulpride.htm
http://www.biopsychiatry.com/amisulpridedop.htm (NOTE: Specifically talks about dopaminergic deficiency with is associated with anhedonia.)And this:
http://www.biopsychiatry.com/sulpiride.htm
So I have no idea if amisulpride is superior to sulpride. Most of the literature on depression is on amisulpride, not sulpride. Both appear to be affective, fairly safe augmenters or primary drugs for minor anhedonia. I'm pretty sure they can be used with an SSRI, although there is no literature that I can find to support this. Seems amisulpride is used as the primary agent and has been shown to have similar efficacy to SSRI's in some studies. Although look at this:
http://www.dr-bob.org/cgi-bin/pb/mget.pl?post=/babble/20020416/msgs/103469.html#103469
Maybe a bad idea to combine? Just try amisulpride trial? Do a search on low dose flupentixol. I think there's some lit on it as an AD but don't have time to look it up for.
I hope this is more helpful than confusing, but I fear it may be the latter. Happy to talk to you any time on these topics. Fascinating to me!
Phoenix1
poster:Phoenix1
thread:806974
URL: http://www.dr-bob.org/babble/20080114/msgs/807122.html