Posted by bleauberry on January 5, 2008, at 21:00:49
In reply to Anyone Know why a Med will Poop out for some?, posted by Phillipa on January 5, 2008, at 20:29:02
I don't know, Phillipa. I guess if someone knew the answer to poopout they could become a millionaire overnight. We know that with a SSRI, serotonin receptors will decrease in numbers over time to compensate genetically for the artifically increased serotonin. The receptors change responsiveness based on the new serotonin. We have no idea what instructions our genes have in various situations. Some drugs eventually effect thyroid function, such as prozac or paxil, due to their fluoride content.
Memantine, an NMDA antagonist, supposedly prevents tolerance to opiates, stimulants, and cannabis, so maybe somehow the whole glutamate/potassium/calcium circuit is somehow involved. Feedback mechanisms might be slow to kick in but eventually get the idea there is too much serotonin and just shut things down. There has been theory that tryptophan conversion into serotonin is altered in a negative way by antidepressants. Don't know. Complicated stuff.I've heard of people happy with prozac for 10 years, and others it poops out in a month. Same with zoloft. I don't know why. Individual genetics.
Does that mean that every so often we will have to stop a drug that has pooped out, return to it later, or start a new one, or augment it with something new? Don't know.
I do know one thing. You are ready for a change. I see absolutely zero sense in continuing with luvox. Your genetics have well figured that drug out and got it beat. If Paxil worked once, maybe again.
While researching SNRIs at pubmed it became apparent that SSRIs generally work better for younger people but not older people, while SNRIs work better for older people but not younger people. You might limit your sights to norepinephrine type drugs...nortriptyline maybe. Paxil by the way has fairly strong norepinephrine action compared to others. Maybe there's a hint in there, why you did well with paxil. Anything but luvox. Please. It's time.
> May seem like a silly question but I really don't understand poopout other than a med that works no longer does for the person length of time seems to vary a lot. If a med works and then poops out then another med right? And this can continue correct or not? If so what happens that the med no longer works or does this mean that you will continually have to find another med. And can you run out of things. I wish I did have one that worked right now I'm just me depending on my strength of will power to continue. And isn't it said that a bout of depression only last a period of time as I've been depressed according to others for many years and did take meds long enough to finish trials. One time luvox worked at 250mg for about two weeks. First ad was l0mg of paxil and xanax and it was working till the doc took me off it for a med trial. So if he hadn't might I still be working and feeling fine as I was then or is this a fallacy. That eventually they all stop working. Thanks for you time to answer. Phillipa ps been depressed without a break for ll years. Benzos have been a savior for sleep.
poster:bleauberry
thread:804537
URL: http://www.dr-bob.org/babble/20080105/msgs/804546.html