Posted by bleauberry on January 5, 2008, at 20:42:38
In reply to why do some AD's trigger rage?, posted by elanor roosevelt on January 5, 2008, at 14:34:23
I think the most popular theory is that when rage/agitation happens it is a sign of bipolar rather than depression. Strange though, if that is true, why a mood stabilizer like lamictal or lithium might actually cause rage. So that makes me think that there is some other neurochemistry that is being thrown too far out of balance by the drug. Too much norepinephrine, dopamine, or serotonin. Not enough GABA. Something like that. I have experienced that kind of rage 3 times in 13 years. Once was when increased prozac from 20mg to 40mg. Another was when I took modafinil or adrafinil monotherapy (they didn't do that when mixed with prozac). The last time was when starting lexapro at a mere 2.5mg. For me it looks like too much serotonin too fast can spark rage. Whether that is a chemical imbalance thing or a sub-bipolar thing, I don't know. If it is a serotonin thing, then I don't understand why a tiny dose of zoloft will end the rage agitation stuff in a matter of hours, and yet lexapro would spark it.
poster:bleauberry
thread:804467
URL: http://www.dr-bob.org/babble/20080105/msgs/804541.html