Posted by Ron Hill on December 14, 2007, at 1:08:24
In reply to Re: Is Deplin available in UK? » Ron Hill, posted by tecknohed on November 25, 2007, at 16:31:05
> Thanks for that Ron. Wonder if they ship to the uk...haven't tried to order yet.
Sorry for my delay in replying.
I don't know about UK availability. This would work, albeit more expensive:
http://www.hsfighters.com/ingredients.htm
> I did read the 'Scientific Review' but still don't understand why you'd need to take active B12 & B6 & why the regular forms of these wouldn't suffice.The reason is analogous to the reason why some pts respond better to L-methylfolate instead of folic acid.
Pyridoxine HCl (B6) must be converted in the liver to P-5-P before it can cross the blood-brain barrier and serve as a reactant and catalyst in neurological biochemical reactions.
In a similar fashion, cyanocobalamin must be converted to methylcobalamin before it can be used in the brain. Further, I refuse to take cyanocobalamin because, as I understand it, cyanide is a reaction product in the conversion.
> Why do you think one Deplin pill contains such a high dose of L-methylfolate (7.5mg?) when its supposed to be so much more bioavailable? Surely 800mcg would be enough? Do you know the reason?I've wondered the same thing. Anecdotally, when I first started taking Deplin, 15 mg/day provided the best response. But, after 38 days of good response from Deplin, I became very depressed and I could not figure out why. I stopped taking Deplin, and the depression went away. Turns out that I needed to dramatically reduce my Deplin dosage after the initial month of start up.
The need to reduce the intake of L-methylfolate as time on the med increases is consistent with the graphs Figure 1 and Figure 2 in the following article.
The article addresses a completely different subject than what we are discussing here, and so do the figures. However, the figures show that the longer the pt takes a constant dosage of L-methylfolate, the red blood cell and plasma concentrations continue to rise.
http://www.ajcn.org/cgi/content/full/84/1/156#F1
So this means that in order to hold the blood level concentrations of folate constant at the optimal therapeutic value, the dosage intake has to be continually reduced the longer and longer that we take the medication. Does this make sense?
> teck-- Ron
Currently in near-full remission.
dx: Bipolar II, with ultra rapid cycling (15 days for one complete cycle), and mild Obsessive Compulsive Personality Disorder (OCPD)600 mg/day Trileptal
200 mg/day Lamictal
875 mg/day Keppra
90 mg/day Nardil
1.875 mg/day Deplin (1/4 of a 7.5 mg tablet = 1.875 mg)
50 mg/day P-5-P
3000 ug/day Methyl-B12A few miscellaneous other vitamins and supplements: zinc, phosphatidylserine, selenium, vitamin D, Mg Malate/dietary Ca in yogurt etc, liquid fish oil, a good daily multiple vitamin.
poster:Ron Hill
thread:795874
URL: http://www.dr-bob.org/babble/20071213/msgs/800713.html