Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Keep posting successes on deplin or methylfolate » stargazer2

Posted by Ron Hill on October 26, 2007, at 23:23:34

In reply to Keep posting successes on deplin or methylfolate, posted by stargazer2 on October 26, 2007, at 21:50:49

Star,

> I have TRD and need to knowif this is something that might help me. I just told my pdoc about it today and he thinks it may be worth trying.

I'd say, give it a try. L-methylfolate is endogenous in your brain already. Deplin just raises the level of L-methylfolate substantially. Side effects are rare, but Deplin can cause insomnia, irritability and a few other things. If it doesn't work for you, simply discontinue it.

I find that 7.5 mg/day is not enough for me. I take 7.5 mg first thing in the morning with the rest of my meds. I can feel the Deplin working about 15 minutes after taking it. However, it begins to wane after about six hours. So, I take another 7.5 mg dose about six hours after taking the morning dose.

The dose-response curve for the plasma level of 6(S)-MTHF (Deplin) verses time is presented at the bottom of this web page:
http://www.deplin.com/HealthcareProfessionals,Deplin

Please notice that at the six hour mark, the plasma level of Deplin is only about a fourth of what it is at the peak. My hunch is that this is why I need a second dose at about the six hour mark.

For those interested, here is the document from which this dose-response curve was originally taken: http://www.nature.com/bjp/journal/v141/n5/pdf/0705446a.pdf

Stargazer, remember that I have only been taking Deplin for five days. And, although I am getting absolutely excellent results so far, it is way too early to know if the benefits will last. Time will tell.

Research followed by trial-and-error is the name of the game when it comes to finding the p-meds that work the best for each particular patient.

-- Ron

Bipolar II with ultra rapid cycling (15 day cycle), and mild Obsessive Compulsive Personality Disorder (OCPD)

600 mg/day Trileptal
200 mg/day Lamictal
875 mg/day Keppra
90 mg/day Nardil
15 mg/day Deplin



Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Ron Hill thread:790747
URL: http://www.dr-bob.org/babble/20071019/msgs/791676.html