Posted by Maria3667 on October 3, 2007, at 4:45:36
In reply to Re: Could strattera be causing depression??, posted by bleauberry on October 2, 2007, at 20:30:18
Hi Bleauberry,
Thanks for clarifying that!
I absolutely agree with the theory about one system influencing the other. Since the 'cascade'-effect' is so complex, I wonder how long before we will be able to truely influence it without upsetting another part of our chemistry...
Of course I'm just a lay person in this misty field of neurotransmitters, but I get the feeling Remeron lowers NE & Strattera hightens NE. Just a hunch, no solid evidence to proove it.
A couple of years ago I read a report claiming the higher the levels of NE are, the more depressed the subjects were. Astoudingly, scientists drew this conclusion on the basis of postmortem examinations of people who'd committed suicide...
May I ask how come you know so much about this subject? Are you studying medicines?
Take care,
Maria
> These drugs are way more complicated than any human can pinpoint.
>
> For example, remeron increased the firing rate of NE. According to our best theories. But it didn't plug up the sink to allow NE to accumulate. Strattera on the other hand plugs up the sink, forcing NE to accumulate, but as a result causes the firing of NE to slow down or shut off as a means to compensate. Sometimes they adjust and sometimes not. I think some people have depression related to the firing or neurons, where others have depression related to the amount sitting in a pool. If someone's depression is caused by hypo-firing neurons, an reuptake inhibitor is probably going to make them feel bad by slowing down the firing even more. The lag time for a drug to work has been theorized as the time it takes for those neurons to adjust and then resume firing. Maybe with nonresponders they never do adjust. Who knows. It's all theory and wild guess.
>
> Like I said though, there are so many other mechanisms of these drugs we don't know anything about. How they affect inborn gene instructions, how they affect the other neuro systems, which areas of the brain they work in, how they affect the immune system, pancreas, liver, intestines, on and on. Lest anyone think any of these other things have nothing to do with mood, they are wildly mistaken. We cannot affect one part of the brain or body without impacting another.
>
> Anyway, I don't know why remeron was ok but strattera makes you feel bad. But if it makes you feel bad, tell your doc you want off.
poster:Maria3667
thread:786241
URL: http://www.dr-bob.org/babble/20070929/msgs/786635.html