Posted by Larry Hoover on August 7, 2007, at 9:46:08
In reply to Re: Prestiq (Desvenlafaxine Succinate) » Larry Hoover, posted by Cecilia on August 6, 2007, at 20:24:21
> Is there a test that there is any chance the average doctor would be willing/able to do that tells you whether you have 2D6 action? Cecilia
No, unfortunately. There are some labs which claim to test 2D6 function, but as far as I can tell, they actually test for specific DNA strands. Last time I checked, there were 118 different forms of the 2D6 gene, and more being reported all the time. Existing methods only check for a handful among the hundreds, making false negatives very likely. If your own gene did turn up on the test, though, the results are iron-clad. One newly developed test trumpets that it detect 13 variants, but as I mention, nearly ten times that many are known already. And those are only the ones that we've troubled ourselves to identify.
The only really useful test would be to monitor the breakdown of a known 2D6 substrate. I think they once used dextromethorphan for this, and measured the hourly concentration of the metabolite in urine. I don't know of any lab doing this today, but this method provides truly practical information. It doesn't matter what genes you've got. It matters how they are working.
Lar
poster:Larry Hoover
thread:773437
URL: http://www.dr-bob.org/babble/20070730/msgs/774547.html