Posted by Squiggles on August 1, 2007, at 9:15:25
In reply to Re: lithium » Larry Hoover, posted by Squiggles on July 31, 2007, at 8:47:25
> I'll get back to you - busy now; at first
> glance many of the things you say are false,
> you use equivocation and interpretation in
> a sophistical manner.
>
> I *am* interested in long-term studies because
> that is what the relevant clinical evidence is
> in the case of renal effects of lithium. And
> as you must know, there is a wide range between
> acute renal failure, nephrogenic diabetes insipidus, globular changes, hormonal failures, and kidney shrinking. As for toxicity--- that
> is about as broad a concept as addiction and carries the same linguistic wars; like how many angels can dance on the head of a pin.
>
> Later
>
> Squiggles
--------------------------- August 1, 2007I tried to post the texts but there were too many unacceptable characters, so here are the url's:
Some articles on renal effects and lithium:
http://sunzi1.lib.hku.hk/hkjo/view/21/2100155.pdf
http://archpsyc.ama-assn.org/cgi/content/abstract/54/1/9
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=424553
http://grande.nal.usda.gov/ibids/index.php?mode2=detail&origin=ibids_references&therow=239687
http://www.emedicine.com/med/topic1313.htm
http://www.healthieryou.com/mhexpert/exp1120103e.html
http://www.antenna.nl/lithium/english/postgrad/vasopressin_ep.htm
http://jpet.aspetjournals.org/cgi/content/full/289/1/443
I think I will stop here now. You can go on with the appropriate key words, and you may already
have. Obviously, the research shows that as far as renal effects go, there is substantial evidence
that the kidneys are affected. This is just one of the effects that lithium has. Personally, I would be
more concerned with the bradycardia that is induced by lithium and does not receive as lengthy
study (as far as i have seen on the net). I have had periods of such an occurrence and neither clinics
nor doctors considered it as significant enough as renal checks.
Regarding renal clearance and kidney changes, my question would be, to what extent this is
a serious pathology enough to change from lithium to say depakote, wich has its own can of worms,
raising weight about 3 to 4 times than lithium and affecting the liver, and causing neurological damage
upon withdrawal. At least with lithium it is possible to have a clearance by stopping it for some time.Also, the effects of lithium toxicity are detectable both personally and through lab tests, and therefore
easy to monitor. In seniors or women, the dose may be lowered, or an adjunct given.Given the incomparable specificity, mental clarity, and suicide prevention that this drug can provide,
the physiological effects should be compared and weighed against other drugs, which can be researched
for more severe side effects.-------------------------
Squiggles
LITHIUM POSTER GIRL
http://www.scripophily.net/secomi.html
poster:Squiggles
thread:772306
URL: http://www.dr-bob.org/babble/20070730/msgs/773253.html