Posted by Squiggles on July 29, 2007, at 10:49:58
In reply to Re: Should all drugs be generic? » Squiggles, posted by Larry Hoover on July 29, 2007, at 10:33:01
> > http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=11999908
> > >
> > > Lar
> >
> > I can find many articles and recent researches on this (see LITHIUM IN NEUROPSYCHIATRY - Bauer, Grof, and Mu[..]ller-Oerlignhausen) that say the contrary.
>
> ??
>
> I presented empirical evidence of kidney function disturbance by lithium, which took me less than 10 seconds to find. It is irrelevant that others exclude data to reach contrary conclusions.
>
> Moreover, I showed one of many kidney disturbances from lithium intake. I've already shown your supposition to be false.
REPLY:
Is it "disturbance" or is it "toxicity" or both--
you seem to be wavering.http://www.emedicine.com/med/topic1313.htm
"The role of lithium in the production of acute renal failure is well accepted. The cause is generally due to severe dehydration and volume depletion due to the combination of natriuresis and water diuresis accompanied by elevated lithium levels, altered mental status, and subsequent poor oral intake. Acute renal failure has also been described as a result of lithium-induced neuroleptic malignant syndrome. However, controversy still exists over its role in chronic renal failure. Boton et al estimated (from an analysis of more than 1000 patients) that 85% of patients on long-term lithium therapy had normal glomerular filtration rates (GFRs); the remaining 15% had GFRs of more than 2 standard deviations below the age-corrected normal values, but very few patients had values less than 60 mL/min.
Extensive reviews in 1988 and 1989 suggested that monitored long-term lithium treatment does not adversely affect the GFR, despite other reports of concurrent histological damage. Prospective studies of patients taking stable lithium also failed to show a decline in GFR in the absence of acute lithium intoxication. Although a minimal increase in the protein excretion rate has been reported in some patients who were taking lithium for at least 2 years, overt proteinuria is not a common complication. A rare association between minimal-change nephrotic syndrome and lithium administration has also been described.
Lithium does not appear to adversely affect proximal tubular function."
-----
Please not Larry, that if you are referring to
nephrogenic diabetes insipidus, i have been tested for that. I am monitored. And, my voiding is almost clockwork regular. See the conditions which may lead to renal failure above.
And keep in mind that other psychiatric drugs also lead to "toxic" effects, under certain conditions; for example cardiac arrest due to prolonged or large dose of some tricyclics.Squiggles
poster:Squiggles
thread:772306
URL: http://www.dr-bob.org/babble/20070719/msgs/772698.html