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Re: What to expect on Desipramine

Posted by linkadge on July 27, 2007, at 12:51:00

In reply to Re: What to expect on Desipramine, posted by greywolf on July 25, 2007, at 21:41:04

You can type in nortryptalie + lithium into a search engine. There have been a few studies I believe on the combination. Most involving post ETC depression relapse prevention. Apparently the combination lead to fewer relapses and more time till relapse.

Both nortryptaline and desipramine are heavy on the noradrenergic side of it. Nortryptaline still has some appreciable affinity for the serotonin uptake pump. Desipramine is even more selective for norepinephrine.

Nortryptaline has a good track record for treatment resistant depression. Some large trials have found it effective for some people who fail SSRI's. This could extend to desipramine.


I think the nortryptaline/lithium combination used augmenting doses of lithium (ie 450-600, so it may still be tollerable if you don't handle high doses well).

Take Care.

Linkadge


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