Posted by rovers95 on July 12, 2007, at 13:29:15
In reply to Re: Ketamine, posted by deniseuk190466 on July 11, 2007, at 15:38:46
> That sounds wonderful but then why do SSRIs etc work so well for some people (like they used to do for me)?
> Also, I can't see how taking Ketamine once every seven days could be seen as a cure it's not making any permanent beneficial changes in the brain.
> And I thought lamcital was supposed to affect glutamate, how come that often doesn't work?
> Having said that, I think Ketamine sounds really promising but would just like to know a bit more about it.
Lamictal works at sodium-sensitive voltage channels, wehereas ketamine inhibits glutamate at the NMDA receptors. The idea is the blockage of "neurotoxic" glutamate at NMDA enables the brain to recover to its pre-depressed state, allowing GABA and dopaminergenic terminals to work more effectively, it also lowers the HPA axis. I also suspect it promotes BDNF etc.