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Re: high dose lithium » big time

Posted by Squiggles on June 27, 2007, at 6:22:07

In reply to high dose lithium, posted by big time on June 26, 2007, at 19:58:47

> hi,
>
> i have bipolar 1 and i take lithium and zyprexa. i want to decrease the zyprexa and increase the lithium, but my pdoc is hesitant to increase it. does anyone have experience with high doses of lithium for maintenance therapy for BD? i know its really old school, but i want to try it
>
> thanks!


Hi,

I wonder what your lithium dose is? I take 900mg per day-- i would prefer lower but my dr. wants the blood level where it is 0.8-1.2. Frankly, i have never been observed on a different blood level, but i trust my doctor.

As for the combo, you may want to look at the interactions between Zyprexa and Lithium:

http://www.drugs.com/drug-interactions/zyprexa_d04050.html

The narrow therapeutic index: ah, yes, well after many yrs. of experience, i would say that it depends very much more on dietary and sodium/potassium/water balance. cumulative toxicity AND interaction with other drugs.

I think that it being such an old drug, it has been monitored for this danger, far more than other drugs which also have a toxity level. "Narrow" is a vague concept when it is not given in actual numbers, and all that is indicative is the actualy toxicity after the fact.

Squiggles


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