Posted by Racer on June 23, 2007, at 14:23:45
In reply to Re: Racer, *Metformin* for weight gain??? » Racer, posted by Zyprexa on June 23, 2007, at 13:29:58
> My doctor is suggesting this. but I worry about anti-diabetics and bad side-effects.
Well, see, there's some evidence that Zyprexa can cause problems with insulin resistance even in the absence of significant weight gain. That would suggest that metformin is a pretty good bet to counter the problem. In fact, I think that's pretty much standard of care these days, although I could be wrong....
What I do know, though, is that a lot of articles have come out in the past year or so, in a lot of journals, about the use of metformin to counter insulin resistance, weight gain, and metabolic syndrome associated with the use of second generation anti-psychotics. The consensus seems to be that it's a pretty darn good idea. The only entity which doesn't seem to like this idea is Lilly, but that's older information, and it's likely they don't want to imply that their drug could be linked to the development of diabetes.
It sounds as though you have some objections to trying it? I'm only curious -- I'm the last person to say, "Ah, just take it..." since I tend to freak out pretty completely at the thought of any med changes. What sorts of things are you worried about with it? Do you think it's worth giving it a try?
OH! Another thing you could try, in the meantime, are H2 blockers like Pepcid, Axid, Zantac, etc. Apparently the benefit is limited to reducing appetite, and tends to wear off after about four months, but it's still worth giving it a try.
I hope that helps.
poster:Racer
thread:764734
URL: http://www.dr-bob.org/babble/20070622/msgs/765225.html