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Re: Easier words » Iansf

Posted by Racer on June 4, 2007, at 18:31:15

In reply to Re: Easier words » Racer, posted by Iansf on June 3, 2007, at 23:59:38

> > What this means, is that Wellbutrin may be more effective at lower doses if given with a low dose of Prozac. Wellbutrin is often not a terribly robust antidepressant on its own, and this suggests that adding a low dose of Prozac might boost its powers.
> >
>
> Is there any way to interpolate the data in terms of human dosage to determine how much Prozac would be needed to potentiate the Wellbutrin, and how low a dose of Wellbutrin might then be effective? Might, say, 5mg of Prozac be sufficient to make 150mg of Wellbutrin effective? Or will we have to wait for followup human studies for any indication in this regard?

Well, you could use the numbers involved in this study, and extrapolate based on body weight, but I doubt it would do a lot of good. For one thing, rats and humans may not respond similarly.

The biggest thing, though, is that this study only looked at how much of the neurotransmitter was available in the brain. That doesn't necessarily correlate to effectiveness as an antidepressant.

So, it's still hit or miss...

I will say, though, that 5mg of Prozac has boosted my 450mg of Wellbutrin XL... Not that that means anything much...


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