Posted by Squiggles on May 25, 2007, at 11:42:32
In reply to Re: Some questions about Lithium., posted by linkadge on May 25, 2007, at 11:17:44
...It does not even lead to symptomatic improvement in Parkinson's or Alzheimers, except in perhaps behavioral control (for agitation etc)
>
You may have a point there. It is experimental,
and behavioral control is a favourite test for many new treatments.
...
>
> >There *are* cases where the tremor mimics
> >Parkinson's, but that is not the same thing.
> >This poor man at 71 had lithium toxicity-- >something which is easily avoidable with >frequent blood tests. Lithium requires regular >check-up, especially at older ages.
>
> Lithium use, as well as SSRI use has been associated with later onset of Parkinsons desease. Although, the counterargument is that mood disorders are a risk factor for Parkinsons and not the treatement.That may be so and the cause may be chronic lithium intoxication. This is something Dr. Schou warned against when he recommended a "lithium holiday". The reason he suggested this is that a blood test cannot show an accurate accumulation rate in the brain, and showing a normal blood level can be deceptive.
>
> This being said, lithium is actually antidopaminergic. It interacts with dopaminergic pathways via its effects on 5-ht1b receptors.
> While this is not proof that it causes parkonsons, it has been associated with onset of parkionsons in a few studies.Are there any ADs or APs that are not antidopaminergic?
>
>
> Squiggles
>
poster:Squiggles
thread:759071
URL: http://www.dr-bob.org/babble/20070524/msgs/759438.html