Posted by linkadge on May 12, 2007, at 9:42:44
In reply to Re: Bi Polar/Recurrent Unipolar and Antidepressant, posted by Squiggles on May 12, 2007, at 8:24:25
>I don't know either. The neurological sciences
>seem to have targeted neurotransmitters of brain >hormones, amino acid transporters like >serotonin, receptors for dopamine, inibitors, >inducers, agonists, antagonists, and on and on.But what has it amounted to? All we really have for depression us uptake ihibitors. To me, some company probably just takes a kazillion compounds and tests which ones have affinity for the serotonin transporter, and then just go through a filtering process.
>Surely, the science of this brain physiology >must be a result of studying the chemistry of >the brain under abnormal and normal conditions. >And on the basis of that study, drugs are >created.Possably. But the evidence is very contradictory. There is only very limited evidence that there really are imballances in serotonin levels in depression. The serotonin transporter does not appear to be involved in depression, and when it is involved, it is involved in ways opposite to what was expected.
For instance if SSRI's work, one would expect depressed people to have *overactive* serotonin reuptake mechanisms. But studies do not show this. Infact, many of the studies show that people with depression have *underactive* reuptake mechanisms. So there goes that theory.
Its all just theory. How can they develop more effective drugs, when they don't even know how the current ones work?
Its BS to think its all methodical, and scientific. It still is a psudoscience.
Linkadge
poster:linkadge
thread:757534
URL: http://www.dr-bob.org/babble/20070509/msgs/758094.html