Posted by kaleidoscope on May 4, 2007, at 15:22:28
In reply to Re: Seroquel can cause weight gain--at what dose? » Honore, posted by Larry Hoover on May 4, 2007, at 6:45:00
Hi Lar
My impression of Seroquel is that while some patients gain little weight, others put on huge amounts of weight. Although less offensive in this department than Zyprexa, Seroquel can certainly cause obesity!
>Ed's source is British, and the American monograph doesn't give precisely the same info.
I got it from seroquel.com
>Well, that's not clear cut. In roughly the same proportions as those who experience these weight gains, we also find: a) significantly increased cholesterol and triglycerides; b) significant decreases in thyroid T4 output; and c) hyperglycemia. I wouldn't be surprised if they also might find changes in the satiety regulators leptin and ghrelin, which go hand in hand with these measured parameters.
Atypical antipsychotics are certainly a very effective means to increase cardiovascular risk factors. Increased appetite is probably one the numerous ways by which Seroquel increases weight. The cardiovascular safety of Seroquel and other APs is particular poor in elderly patients w/ dementia.........hence the FDA's blackbox warning.
'Increased Mortality in Elderly Patients with Dementia-Related Psychosis
Elderly patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death compared to placebo. Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks) in these patients revealed a risk of death in the drug-treated patients of between 1.6 to 1.7 times that seen in placebo-treated patients. Over the course of a typical 10 week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular (eg, heart failure, sudden death) or infectious (eg, pneumonia) in nature. SEROQUEL (quetiapine) is not approved for the treatment of patients with Dementia-Related Psychosis.'
Ed
poster:kaleidoscope
thread:753509
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