Posted by Larry Hoover on March 12, 2007, at 12:13:07
In reply to Re: What do people make of this warning?, posted by linkadge on March 12, 2007, at 11:46:57
> http://www.best-meds.com/drugdescription/lamictal_warnings.htm
>
> Binding in the Eye and other Melanin Containing Tissues: Because lamotrigine binds to melanin, it could accumulate in melanin rich tissues over time. This raises the possibility that lamotrigine may toxicity in these tissues after extended use. Although ophthalmological testing was performed in one controlled clinical trial, the testing was inadequate to exclude subtle effects or injury occurring after long-term exposure. Moreover, the capacity of available tests to detect potentially adverse consequences, if any, of lamotrigine's binding to melanin is unknown.
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> LinkadgeOne investigation showed measurable lamotrigine residue in the rat uveal tract (highly melanin rich fibrous layer within the eye) 52 weeks after a single exposure. Coupled with the absence of any reported opthalmological abnormalities associated with Lamictal, I'd lean towards the concept of a highly stable artefact of treatment. A curiosity. You can't prove the absence of an effect scientifically, but nobody has yet reported that there is one, as far as I can tell.
Lar
poster:Larry Hoover
thread:740184
URL: http://www.dr-bob.org/babble/20070308/msgs/740400.html