Posted by valene on March 12, 2007, at 9:41:06
In reply to Re: Benzo's » notfred, posted by yxibow on March 11, 2007, at 23:57:14
> > > How long can Benzo's stay in your system?
> >
> > people are confusing 1/2 life, which does not tell you how long a drug can be tested for.
> >
> > Benzos are fat soluble drugs, they can be still detected at and up to a month. Flushing has limited effectiveness in fat soluble drugs, taken to Nth degree your sample will be judged invalid if it is too dilute. Other dodges with herbals
> > effect pH of the sample; while this can render a test impossible it also will be detected. pH and specific gravity of the sample are measured and you can be considered having a dirty test if they are out of range.
>
>
> Only some benzodiazepines are lipophilic, the lipophilic benzodiazepines have a shorter onset of action than the water soluble agents. They have a shorter CNS effect and are distributed to fat tissue. Lorazepam has a longer CNS duration of action than diazepam because diazepam is lipophilic and lorazepam is not. [Emedicine]
>
> Xanax is rather lipophilic and has a very short onset, the immediacy effect that I was mentioning before.
>
> This isn't the complete story of benzodiazepines as they have multiple metabolites. Diazepam still has a long half life.
>
> And then there's the general dose argument that is used which approximates nonlinear curves, so a drug is "out" of the system in 5 half lives.
>
> ---
>
> In general, high potency benzodiazepines:
>
> Xanax, Ativan, Halcion (short half life)
> Clonazepam (long half life)
>
> Low potency:
>
> Librium, Tranxene, Valium, Dalmane (long half life)
>
> (Am Fam Physician 2000; 61:2121-8.)
>
> "Pharmacologic properties such as potency, half-life and lipophilicity, the duration of treatment and the rate of a dosage increase or decrease have a bearing on the occurrence of side effects. 1"
>
> "1. Salzman C, for Task Force on Benzodiazepine Dependency, American Psychiatric Association. Benzodiazepine dependence, toxicity, and abuse: a task force report of the American Psychiatric Association. Washington, D.C.: American Psychiatric Association, 1990."--------------------------------
Interesting. Salzman (mentioned above) was the psychopharmacologist I saw last year in Boston who recommended I stay on low dose xanax. He is a pro-benzo doctor.Xanax is one benzo that has no metabolites. I was under the impression that benzos with active metabolites stayed in your system longer?
poster:valene
thread:739648
URL: http://www.dr-bob.org/babble/20070308/msgs/740364.html