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Low binding = increased serotonin activation

Posted by hgi698 on February 23, 2007, at 16:42:57

In reply to Buspar Increasing Religiosity, posted by hgi698 on February 22, 2007, at 23:52:15

I think what they said in the study is that people who had the lowest binding of the 5-ht1a receptor were the most religious. I think from a neuroscience point of view, lower binding means a lower receptor amount. Usually a lower serotonin receptor amount is due to increased activation of that receptor so it is downregulated in response. This would indicate that increased activity at the 5-ht1a (i.e. an agonist) is associated with increased religiosity. I am almost positive that my experience was due to post-synaptic 5-ht1a receptor activation as opposed to the somatodendritic autoreceptor.


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