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Re: Are MAOIs ever ineffective?

Posted by halcyondaze on February 19, 2007, at 17:22:11

In reply to Are MAOIs ever ineffective?, posted by UgottaHaveHope on February 19, 2007, at 11:51:48

Well, there was the STAR*D depression study that found lower efficacy rates of Parnate as compared to Effexor XR + Remeron. However, the maximum dose was 60 mg/day and in people who had ALREADY failed the first four antidepressant stages, I'm guessing that 60 mg/day was simply not sufficient for most. Also, it was not "blinded" because they required that people do a 2 week washout (no wash out was required for the other group) as well as dietary restrictions. Many might have been uncomfortable with taking a MAOI, leading to a high drop out rate. Also, the two week washout period might have increased the depression from coming off the LAST medication in the 3rd stage of the trial and it was not given an adequate chance to work. Titration was pretty slow.


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