Posted by willyee on February 18, 2007, at 9:34:43
In reply to Re: Why Most New Antidepressants Are Ineffective, posted by blueberry1 on February 18, 2007, at 6:03:26
> The title is misleading. Forget the clinical studies. Go to remedyfind.com and askapatient.com to see real world people experiences with ssris. A good number of them do very well with ssris. The title is an inaccurate over-generalization.
>
> I understand the manipulation of clinical data, ghost writers, big pharm influence, and behind the scenes scandals of facts. That stuff really disturbs me.
>
> Regardless, judging from real world experiences with ssris, it appears maybe 35% - 45% of people really benefit from them. That is a far cry from saying they are ineffective.
>
> I'm not sure why he praises parnate so much. There have been plenty of people here and other places that did poorly with. Side effects often require 2 or 3 other meds to deal with, when it works. I would guess in the real world the actual positive benefits of parnate compared to ssris are probably a little higher than ssris, but not enough to totally trash ssris and put parnate on a pedestal.
>
> Anyway, bottom line, mileage varies. I totally respect the authors views, but feel the title is a bit inaccurate and overgeneralized.Actualy ive read and i wish i had the article/articles handy that documented studies did show parnate to be one of the most fast & effective drugs for depression,Nardil the old one as well,in fact the old Nardil used to be nick named the GOLD STANDERD.
Along with the parnate statistics however the drug prob holds the highest or close to addiction potential,so you always get some form of major con.
Your right however,studies from any source,PERIOD doesent overide actual experiance,and mileage varies,although i do agree with the findings i also agree if someone does well on any drug that is helpng all around then they have no reason to look else where just because of some documented study.
Remedyfind shows parnate less effective overall because u can see the users invovled are far far far less than a user of ssris,this is prob common since again maois are strayed by most docs as not to be used.
Also,like maois,most people on ssris will also have a adjunct med like a benzo or mood stablizer as most ssris,especaily when working well tend to cause some over excitement,im sure you know the term polypharmacy which is multiple drugs used,and with the complex way the brain works,during the lentgh of a day it actualy makes sense that more than a single drug would be best.
Sadest thing of all to me is that a drug "parnate" from the what..50`s is still even considered one of the better ones,it just shows to me the slow advancments were making,i truly believe as long as patients listen to docs about not going off on there own to research,sometimes scared into doing a thing without talking to them,etc,.....as long as these drugs and cousin drugs make such big money,im afraid and almost certain i wont see any serious new line treatments in my lifetime,and ill be either off or juggling drugs for a very long time.
All debates aside,everyone has a similiar goal,and if you feel better on any form of treatment,then recomend it as a option,and from there on dont worry what others say and enjoy it,we spend to much time defending what works i think,aim to live life as full as you can !
poster:willyee
thread:733613
URL: http://www.dr-bob.org/babble/20070213/msgs/733784.html