Posted by psychobot5000 on February 2, 2007, at 13:16:18
In reply to Why don't they make a transdermal Nardil?, posted by saturn on February 1, 2007, at 23:00:57
Because Nardil is unselective for MAO, so there would still be dietary restrictions at any dosage.
It's the fact that selegiline is only a moderately powerful, reversible inhibitor of MAO-a, COMBINED with the transdermal release, that allows enough gut-MAO to be available to keep us safe from tyramine in the EMSAM preparation.
That said, it does seem as though a transdermal release of tranylcypromine or nardil would at least reduce somewhat the risk (and severity?) of hypertensive crisis--allowing us to breathe a little easier. But I doubt it would change the labeling restrictions. It'd just let people eat 20mg/day of dietary tyramine instead of 8mg. Or something like that.
Psychbot
PS--last time I heard, EMSAM was not doing well financially, so it seems to be unlikely we'll see any other MAOis in that format any time soon. Pity.
poster:psychobot5000
thread:728900
URL: http://www.dr-bob.org/babble/20070201/msgs/729081.html