Posted by kelv on January 17, 2007, at 17:18:50
In reply to Re: AMPHETAMINE-DEPRESSION STUDIES NOT ALWAYS CORR, posted by linkadge on January 17, 2007, at 16:33:47
> >yes, but us humans are all euphoria addicts, and >a bottle of Dexedrine in ones possession often >produces a more, more, more, pattern of use
>
> Not necessarily. There is a tremendous amount of research these days into the neural basis of addiction. It has long been known that two individuals exposed to the same amount of drug vary widely in their respone, and further desire
> to abuse it.
>
> For instance, one avenue of research shows that animals with higher levels of GDNF are less likely to abuse drugs. Whether or not they still get high is uncertain. Drugs like ibogaine are thought to work in part at least, by bostling levels of GDNF.
>
> The activation of addiction genes intermediate early genes (ie cFOS, delta FosB) also varies from person to person. So one person might take a drug and crave it for months due to heavy activation of addiction genes, while another person does not.
>
> Some people say marajuanna is addictive. Could have suprised me. I smoked a little and that was ok, but more than htat just made me feel weird.
>
> >i have too often read of where ones Monthly >supply goes in days-i know of one such >individual whos 480 Dex 5mg script goes in a >couple days binging, but again here i am talking >of folks 'chasing a high' not widespread >responsible use.
>
> I know people like that too. I don't really blame people for that response.
>
> >Early hopes that amphetamines would prove to be >an effective general treatment for severe >depression were soon disappointed. Amphetamines >often produce dependency when taken for longer >than two or three weeks.
>
> But yet they do not always produce dependance in those who use them for ADHD?
>
> >Although these drugs are powerful stimulants and >increase a depressed person's activity, they may >also make him more anxious and agitated,
>
> So can wellbutrin for some, but that doesn't mean it isn't a good drug for some.
>
> >deprive him of sleep,
>
> Welcome to my life on SSRI's
>
>
> >and may fail to elevate his mood or to reverse >the fundamental depressive process.
>
> And we all know how effective SSRI's are at reverseing the fundimental depressive process.
>
> >In some individuals, these drugs have been >effective in relieving mild depression and >chronic fatigue, however
>
> Interesting sidenote.
>
>
> Linkadge
>
>Hey,
I agree with everything you have said, i was surfing and came across that older study (when Amps were being tightened down on)and thought i'd throw it in for opion and converse.
yes-i have read on Remedyfind that Adderall, Dex, often rate highly in depression scores, and have saved a couple people reported from long term TRD, and while they MAY poop out, 2-3-5 years, althought many continue to use for years successfully, so do SSRIs
--"The activation of addiction genes intermediate early genes (ie cFOS, delta FosB) also varies from person to person. So one person might take a drug and crave it for months due to heavy activation of addiction genes, while another person does not."
Interesting, i think i'v read something on Coke and cFOS activation. I guess thats why we have our own DOC-drug of choice!
poster:kelv
thread:721931
URL: http://www.dr-bob.org/babble/20070113/msgs/723326.html