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Nardil Treatment of Anxiety

Posted by jedi on January 11, 2007, at 23:42:14

In reply to Re: Jedi thanks and ..., posted by UgottaHaveHope on January 11, 2007, at 22:12:01

> My pdoc keeps saying that Nardil works for social anxiety and not GAD, yet I keep reading posts like yours which say it also helps GAD

Here is one abstract of a study showing Nardil's effect on GABA and anxiety: Jedi

1: Psychopharmacology (Berl). 1996 Sep;127(1):19-24.
The antidepressant drug phenelzine produces antianxiety effects in the plus-maze and increases in rat brain GABA.
Paslawski T, Treit D, Baker GB, George M, Coutts RT.
Department of Psychiatry, University of Alberta, Edmonton, Canada.

Research on the effects of antidepressant/ antipanic drugs in animal models of anxiety has yielded equivocal results, even after chronic drug regimens. In contrast, we found that the antidepressant/antipanic drug phenelzine, given acutely, produced a clear anxiolytic effect in the elevated plus-maze, a widely-used animal model of "anxiety" that is primarily sensitive to benzodiazepine-type anxiolytics (e.g., diazepam). Furthermore, the effective dose of phenelzine (15 mg/kg) administered to rats was associated with more than a 2- fold increase in whole brain levels of gamma-aminobutyric acid (GABA), whereas an ineffective dose of phenelzine (5.1 mg/kg) did not significantly change GABA levels. The N-acetylated metabolite of phenelzine, N2-acetylphenelzine, produced neither an anxiolytic effect in the elevated plus-maze nor a significant change in whole-brain levels of GABA. However, both phenelzine and N2-acetylphenelzine potently inhibited monoamine oxidase, a mechanism commonly thought to be involved in the therapeutic effects of monoamine oxidase inhibitors such as phenelzine in the treatment of depression in humans. These results suggest that the mechanism whereby phenelzine produces anxiolytic effects in the plus-maze model is unique to a facilitatory action on brain levels of GABA, in contrast to classical benzodiazepines, which produce anxiolytic effects by enhancing the affinity of the GABAA-receptor for GABA.

PMID: 8880939 [PubMed - indexed for MEDLINE]


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URL: http://www.dr-bob.org/babble/20070107/msgs/721541.html