Posted by yxibow on January 10, 2007, at 16:23:48
In reply to Re: Correction, posted by Quintal on January 10, 2007, at 15:15:40
> Earlier I wrote:
>
> >High doses of Remeron are actually less stimulating than lower doses because of the stronger noradrenergic (alerting) effects at high doses.
>
> I really meant:
>
> High doses of Remeron are actually less sedating than lower doses because of the stronger noradrenergic (alerting) effects at high doses.
>
> %$*^%! Typos!
>
> QThis is supposedly a general idea but I don't believe I ever saw that -- highest was 52.5 I think -- maybe the few who can stand 90mg of Remeron can get that.
Seroquel is by far the most sedating of the two but its half life is much less and generally taken at night so its sedation wears off earlier in the day for those who can get by with single dosing. Still residual sedation with Seroquel, if I can remember anything about Remeron, I would say that Seroquel is still more sedating.
But interestingly enough at higher doses, Remeron acts partially like Seroquel with a 5HT blockade for some in addition to Remeron's alpha adrenergic quality, so maybe that's your question here. I first took Remeron with multiple split doses to minimize the sedation but eventually started to combine them. So there is sedation with both I'm afraid. But Remeron, a tetracyclic, is still a very good antidepressant for MDD provided one heeds a restrictive diet/food intake due to its significant weight gain factor which may not go away at high doses. As they say, your miles may vary.-- Jay
poster:yxibow
thread:720984
URL: http://www.dr-bob.org/babble/20070107/msgs/721132.html