Posted by cache-monkey on January 7, 2007, at 12:53:09
In reply to Re: Remeron, anxiolysis, posted by cgd092 on January 6, 2007, at 23:37:54
Remeron's most selective as an antagonist of the H-1 receptor, followed by the 5-HT2A/2C receptors. And then at higher doses, it blocks the alpha-2 receptor. See: http://www.preskorn.com/columns/0003.html
I believe that it's a combination of the anti-histamine and 5-HT2 blockade that's responsible for Remeron's anxiolytic properties.
The alpha-2 antagonism is supposedly energizing at higher dose because this leads to a higher NE release. But this can cause anxiety for some people, similar to the herbal yohimbine. But if you're like me and have a super-sensitive NE system (based on how I respond to other meds), you might get increased anxiety even at lower doses.
Good luck,
cache-monkey
poster:cache-monkey
thread:719997
URL: http://www.dr-bob.org/babble/20070107/msgs/720181.html