Posted by jimmygold70 on December 26, 2006, at 11:36:33
In reply to Re: Low dose Naltrexone??, posted by Jimmyboy on December 26, 2006, at 11:09:41
Effects of chronic treatment with methadone and naltrexone on sleep in addicts
Journal European Archives of Psychiatry and Clinical Neuroscience
Publisher Steinkopff
ISSN 0940-1334 (Print) 1433-8491 (Online)
Subject Medicine
Issue Volume 246, Number 6 / October, 1996
Category Original Paper
DOI 10.1007/BF02189023
Pages 305-309
SpringerLink Date Friday, September 30, 2005
Original Paper
Effects of chronic treatment with methadone and naltrexone on sleep in addicts
J. Staedt1 , F. Wassmuth1, G. Stoppe1, G. Hajak1, A. Rodenbeck1, W. Poser1 and E. Rüther1(1) Department of Psychiatry, Georg August University, D-37075 Göttingen, Germany
Received: 22 December 1995 Accepted: 3 June 1996
Abstract Previous studies have described sleep disturbance secondary to chronic opiate use and abuse. Drug-dependency insomnia is of interest because chronic sleep disturbances can promote depressive symptoms which could lead to a drug relapse. For the first time we compared the polysomnographic parameters of 10 methadone-substituted outpatients and 10 naltrexone-treated outpatients. Methadone (-opioid agonist) produced a marked fragmentation of the sleep architecture with frequent awakenings and a decrease in EEG arousals. In comparison with methadone and controls, the naltrexone (-opioid antagonist) group showed the shortest sleep latency and the longest total sleep time. These data indicate that -agonists and -antagonists have different effects on sleep. The implications, especially the involvement of opioid-dopamine interactions on sleep and movements during sleep, are discussed.
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