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Re: Oral dosing equivalence is very, very high » psychobot5000

Posted by CrimsonVik on December 19, 2006, at 19:19:29

In reply to Oral dosing equivalence is very, very high, posted by psychobot5000 on December 19, 2006, at 15:08:18

> It is almost impossible to get an equivalent to 6mg EMSAM from oral selegiling--the doses would be alost absurdly high. --According to my math, you would need not five or ten mg, but 102mg of oral tablets to equal just a 6mg EMSAM patch. This is because the transdermal system is far more effective at getting it into your bloodstream. The oral version has 4.4% bioavailability, compared with about 74% from the patch--about seventeen times higher.
>
>
> As far as I understand, the normal max-dose for oral pills is 60mg, but that some docs push it to about 85mg. It's still not equivalent to EMSAM, as far as I understand, but you also have to deal with significant levels of amphetamine metabolites that are almost absent in the patch. And there are the dietary restrictions. So basically, the two delivery systems are not really equivalent in terms of their effects.
>
> Here's some more of my blather about it:
> http://www.dr-bob.org/babble/20061206/msgs/711307.html
>
> Psychbot
>
>
> > Is the 6 mg patch the equivalent of 5 mg pill or 10 mg (2 pills)?
> >
> > SG
>
>


_________________________________________________

I will ask my Dr. next week what the closest oral dose to the 6 mg. patch is and report back.
I think my dose of 20 mg. is stronger than SG wants. At first it's like a diet pill...it hits you fast, unlike the patch.

Vik


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poster:CrimsonVik thread:703921
URL: http://www.dr-bob.org/babble/20061217/msgs/715090.html