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Re: neurotransmitter tolerance/poop out downregula

Posted by medievil on December 10, 2006, at 9:55:24

In reply to Re: neurotransmitter tolerance/poop out downregula, posted by medievil on December 10, 2006, at 9:38:59

i think i am into something
i have been researching Naltrexone too, and it doesnt seem to be working for everyone, probebly because it doesnt work on CCK directly
i beleive there would be more succes using CCK antagonists directly in preventing AD poop out

CCK2 receptor-deficient mice have increased sensitivity of dopamine D2 receptors.

Department of Physiology, Biomedicum, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia. sulev.koks@ut.ee

The present study supports a role of CCK(2) receptors in the regulation of dopamine neurones. In pharmacological studies conducted on male CCK(2) receptor-deficient mice the changes in the activity of dopamine system were established. A low dose of dopamine agonist apomorphine (0.1 mg/kg), stimulating the pre-synaptic dopamine receptors, induced significantly stronger suppression of locomotor activity in mutant mice (-/-) compared to their wild-type littermates (+/+). The administration of amphetamine (3-6 mg/kg), a drug increasing dopamine release, caused a dose-dependent stimulation of locomotor activity in wild-type mice. In mice lacking CCK(2) receptors, a lower dose of amphetamine (3 mg/kg) tended to suppress the motor activity, whereas the higher dose (6 mg/kg) induced the significantly stronger motor stimulation in mutant mice. Moreover, in the CCK(2) receptor-deficient mice the affinity of dopamine D(2) receptors, but not 5-HT(2) receptors, was increased. Altogether, the targeted genetic suppression of CCK(2) receptors increased the sensitivity of pre- and post-synaptic dopamine D(2) receptors.


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poster:medievil thread:712111
URL: http://www.dr-bob.org/babble/20061206/msgs/712117.html