Posted by Squiggles on November 30, 2006, at 10:51:22
In reply to Re: Maybe all drugs are like this, posted by linkadge on November 30, 2006, at 10:12:14
> >actually effect the same areas of the brain
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> Lithium and valproate are similar on certain domains. Their ability to inhibit PKC-epsilon, GSK-3b, and increase BCL-2, and BDNF, but they are *not* identical in all their actions.
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> If they were identical in their actions, then lithium would be effective for epilepsy which it is not. They have similarities, but the sum of a lot of experience says that the two are usefull for different varients.
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> There are people who respond to one and not the other, for instance.
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> Linkadge
>I can't argue with that :-)
How about a combination of lithium and
valproate? Right now, i think the clinical
guidelines are to give lithium with clonazepam,
which present serious problems upon withdrawal,
or maybe even displacement in dose fluctuations.
I read in the Merck that one drug can displace another. Excuse my layman's understanding.
Clonazepam presents serious withdrawal, like
epileptic fits upon "displacement[if that is
what is happening in lithium dose fluctuation];Squiggles
poster:Squiggles
thread:708634
URL: http://www.dr-bob.org/babble/20061129/msgs/708961.html