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Re: changes in NMDA receptor function

Posted by linkadge on November 20, 2006, at 15:22:22

In reply to changes in NMDA receptor function » linkadge, posted by Caedmon on November 19, 2006, at 18:22:04

There is a slight difference. The neurotrophic theory of antidepressants is that hippocampal neurogenesis is critical for clinical improvement, ie the drug must grow new brain cells to work.

The NMDA receptor adaptation theory says that after repeated exposure to antidepressants there is a regional dampening of glutamatergic function. Ie the drug tames overactive limbic activity which may be present in neurotic types of depression.


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URL: http://www.dr-bob.org/babble/20061117/msgs/705566.html