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Re: Barbs and Benzos ed_uk

Posted by Quintal on November 16, 2006, at 15:11:59

In reply to Re: Barbs and Benzos Quintal, posted by ed_uk on November 16, 2006, at 12:50:26

Hi Ed,

>Phenobarbital is quite different to the barbiturate hypnotics. Its subjective effects are different. Pheno is the only barb which is a powerful anticonvulsant at sub-hypnotic doses.

Its analogue mephobarbital and related drug metharbital are also useful barbiturate anticonvulsants ;-)

>Pheno and the other barbiturates act at different receptors to the benzos.

I wonder if that is why alcohol does not work for me any more (in fact I find it quite repulsive since withdrawing from benzos)?

> The use of pheno to treat benzo withdrawal symptoms does not appear to be a good idea.

My experience would confirm that to anyone thinking otherwise. I had some Neurontin, Baclofen and Phenobarbital and after the first two had little effect Pb was my last resort, the logic being that it would raise GABA and thereby help me feel calmer and help me sleep, which seems reasonable when you consider its general depressant action.

Do you think it is the benzodiazepine receptor that creates those feelings of emotional warmth and safety that I associate with clonazepam? I've noticed this effect is far from universal as an online friend recently started clonazepam and he plunged immediately into a deep depression. Clonazepam continues to have that effect on him now no matter how small the dose. I'm wondering if that effect is at least partly due to anticipation now?

I've suggested Xanax in the hope it will have some antidepressant action, but he now has his heart set on Solian. Xanx had hardly any effect on me, can you shed any light on the pharmacology behind these different reactions Ed?





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