Posted by kingcolon on November 7, 2006, at 11:49:55
In reply to Treatment Resistant Social Anxiety!, posted by Tom Twilight on October 25, 2006, at 12:34:58
I also have TR SA; Nardil worked for 6 months. I've also got TRD and am augmenting Cymbalta and Lamictal with Requip for its dopamine agonism. I've found the latter makes me more assertive. But here's a wild card--my sleep was poor and I wake with lots of anxiety and I have not responded to Seroquel or trazodone, and have a history of substance abuse many years ago, so my doc and I decided to try low dose baclofen. It's an old drug used for muscle spasms, but is mildly sedating and anxiolytic, and is now being intensely studied in alcohol, cocaine and opiate addiction prevention of relapse. It is not addictive, although you have to taper it slowly to avoid a discontinuation syndrome. It resembles phenibut and GHB in that it stimulates GABA B receptors. I've used GHB in the past and found it helped my social anxiety better than anything (phenibut makes me ill). Since starting baclofen, 20 mg for sleep, I find I am less anxious and get back to sleep better, and that the effect carries over into the day, with less general anxiety and improved social anxiety. I wonder if more research should be done on use of this agent in anxiety disorders, and SA in particular.
Anybody used baclofen?