Posted by Squiggles on November 5, 2006, at 18:30:34
In reply to Re: wait a second?, posted by clint878 on November 5, 2006, at 18:02:01
> Well, I agree that lithium is probably a protective agent, so there's no argument there. An interesting question would be whether people who are treated with lithium have superior performance on these cognitive tests to people who are not treated with any medication.
If you mean while on lithium versus "normal" people, then you would be asking for a test
on increased intelligence, right? I don't know.
But the clinical interest for neurogenerative agents such as lithium is more for degenerative diseases which affect cognitive function, such as Parkinson's.
> The issue with performing such a comparison is that the lithium-treated patients will perform better simply because they probably feel better in terms of mood. There would need to be strict controls on mood symptoms to determine that.
That would apply to all drugs that alleviate anxiety and depression, as these conditions distract people from thinking clearly.
> Second, I don't understand why very little research is being done on this topic of cognitive dysfunction. There are all sorts of drugs in the pipeline to control acute mania, for example. While there are drugs that have been shown to combat this dysfunction (like galamantine), there is no established standard of care like there is for mood symptoms. Perhaps there's more money to be made on the former.
Is galamantine Wellbutrin? or is it a condition?
I think a mood disorder is far more important in a person's life than whether he can read Kant or cant.:-)
> Something like 70% of patients with bipolar disorder are disabled. My guess is that the major contributor to this disability burden is cognitive dysfunction, not mood symptoms.
I don't think so. Anyone who has gone through the mania and depression will tell you how alien the experience is; how terrifying and debilitating. Infact, cognitive status is hardly changed except for the way it is swayed by the violent emotions.
> Why do I make this guess? I can say this from experience. I graduated with a master's degree in computer science, and started out with a very well-paying job, but now I have difficulty following conversations at work. Writing is not a problem, but listening to people leads to no understanding, and often to embarrassment when I say something that implies I completely misunderstood the topic.
To me that sounds like undertreated depression
or just plain burn-out.
> Yet, my mood is the best it has been in my entire life. Unless something changes soon, I will probably be forced out of this job eventually. Maybe I can work from home where I don't need to deal with people in real-time.
You sound very familiar.
> Heck, this post took me almost an hour to write and proofread, because my memory is so poor that I continually forget what word I was going to use next.
I don't even pay attention to such detail.
> Could something else be causing these problems? Sure. But it would have to be very coincidental that they began the same day the mania began, before I took any medication, and haven't remitted since.
I don't know -- there are many possibilities - you can't pin it on one thing-- check it out with a biologically inclined doctor.