Posted by zeugma on October 29, 2006, at 16:24:48
In reply to Re: Tolcapone Improves Cognition and Cortical Informat » zeugma, posted by ed_uk on October 29, 2006, at 10:25:06
you're welcome Ed.
it is unfortunate that there are no non-hepatoxic COMT inhibitors in the pipeline anwhere, as far as I can can tell. Many European countries are critical of the FDA's choice to bring tolcapone back to the market, because entapocone, despite its lack of BBB penetration, works just as well in augmenting L-Dopa in Parkinson's patients. I wish pharmacagenetic research- which shows that COMT genotype significantly affects the response to atypical antipsychotics as well as to stimulants- would be taken more seriously by the drug companies, which might spur them to develop a centrally acting and safer COMT inhibitor.
-z
poster:zeugma
thread:698096
URL: http://www.dr-bob.org/babble/20061028/msgs/698787.html